The hosts are third in Group E on two points, while neighbours Rwanda are bottom with just one to their name, meaning both sides are playing catch up on leaders Mali.
Rwanda kicked off their qualifying campaign with a 1-0 loss to Mali last month, with Hatayspor midfielder Adama Traore scoring the only goal of the contest.
The Wasps did manage to get off the mark four days later, though, with a 1-1 draw at home to Kenya, ensuring that their hopes of finishing top are not dead and buried just yet.
Indeed, that narrow loss to Mali is one of only two suffered by Rwanda in their last 13 outings. That includes a run of seven draws, six of those finishing goalless.
If nothing else, then, Vincent Mashami’s men are a tough side to beat and that could be bad news for a Uganda side in need of a victory.
The Cranes have been held to goalless draws by Kenya and Mali in their opening two matches, placing them level on points with the former and two points behind the leaders.
Uganda are now without a win in 10 matches overall since November 2020, four of those finishing by the same 0-0 scoreline.
Three of the last four meetings between these sides have finished level, though Uganda have the better overall record with 14 wins to Rwanda’s 10 victories.
The Group E rivals meet against in Uganda three days after this showdown at Nyamirambo Regional Stadium.